August 14, 2011

2010 consensus conference on liver transplantation for HCC: Should we use living donor grafts for patients with hepatocellular carcinoma (HCC)?


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This article examines the ethical considerations around using living donors for liver transplantation for recipients with hepatocellular carcinoma. The authors summarize the discussion and recommendations of a 2010 consensus conference on this issue and answer three questions:  Why is live donation necessary at all and is it different for patients with HCC? What is double equipoise and how is it affected by the diagnosis of HCC? Is paired exchange appropriate if one or both recipients have HCC? They conclude that living donors can be ethically used for recipients with hepatocellular carcinoma, even if their tumors exceed Milan criteria, as long as certain issues regarding prognosis and the psychological and social considerations of the donor-recipient pair are considered.

Liver Transplantation

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