October 30, 2012

A 1-Year Randomized, Double-Blind, Placebo-Controlled Study of Intravenous Ibandronate on Bone Loss Following Renal Transplantation


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Bone disease post-transplant is a common problem, related to pre-transplant bone disease as well as immunosuppression. This randomized controlled trial assessed the effect of adding IV ibandronate to a regimen of calcium and calcitriol in patients post-renal transplant. Surprisingly, there was no benefit on bone density in the lumbar spine compared to the control group, and only a modest increase in the femur and radius. Also, no study in renal transplant has yet shown that bisphophonates decrease the risk of fractures post-transplant.

Renal Transplantation

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