October 1, 2011

A multivariate analysis of pre-, peri-, and post-transplant factors affecting outcome after pediatric liver transplantation


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The goal of this study was to identify significant, independent factors predicting 6 month patient and graft survival after pediatric liver transplantation, utilizing data from the Studies of Pediatric Liver Transplantation (SPLIT) registry.  Established in 1995, this international multi-center database currently houses data on more than 4,000 children who have undergone liver transplantation in the US and Canada.   The time point was chosen to be most reflective of the congruence of the many different factors influencing outcome from the time of listing to 6 months after transplant.  From a total of 42 pre-, peri- and post-transplant variables evaluated in 2982 pediatric recipients of a first isolated liver transplant registered in SPLIT, the most significant factors predicting patient and graft loss at 6 months in children listed for transplant were post-transplant surgical complications, including re-operation, hepatic artery thrombosis, portal vein thrombosis, bowel perforation, septicemia, and re-transplantation, with reoperation for any cause having the overwhelmingly increased risk of either death or graft loss at 6 months.

Liver Transplantation

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