A prospective interventional study on the use of extracorporeal photopheresis in patients with bronchiolitis obliterans syndrome after lung transplantation
Extracorporeal photopheresis (ECP) is established therapy for palliation of cutaneous T-cell lymphoma, and also effective in other T-cell mediated diseases such as acute and chronic graft-versus-host disease. Indications for use of ECP in acute and chronic rejection in lung transplantation have not been established. This prospective observational study compared rate of change in lung function before and after the initiation of ECP in 51patients with BOS ≥ stage 1. Thirty-one patients responded to ECP with sustained stabilization of lung function over 6 months. These patients had improved graft survival compared to BOS patients not treated with standard therapies without ECP. The ECP-responders had a shorter time between transplant and development of BOS.