September 27, 2010

A Systematic Review on Steroid Withdrawal Between 3 and 6 Months After Kidney Transplantation


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Rapid steroid withdrawal within 1 week of transplantation is associated with an increased incidence of acute rejection, and no clear reduction in side effects or cardiovascular disease risk. This paper combines all studies of steroid withdrawal at an intermediate time point post-transplant in patients treated with cyclosporine or tacrolimus, mycophenolic acid and no antibody induction. It showed no increase in graft loss or death with steroid withdrawal. Interestingly, it showed an increased rate of acute rejection in cyclosporine-treated patients, but not tacrolimus. These results need to be confirmed with larger studies.

Renal Transplantation