June 18, 2011

Alloimmunity-Induced Autoimmunity as a Potential Mechanism in the Pathogenesis of Chronic Rejection of Human Lung Allografts


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Bronchiolitis obliterans syndrome remains the leading cause of morbidity and mortality after lung transplantation.  This retrospective study shows the development of donor specific antibodies during the period following lung transplantation is correlated to BOS as well as the development of antibodies to self-antigens.  Using a sensitive solid-phase assay to detect DSA, the authors demonstrated 42.7% of lung transplant patients developed DSA post transplant.  Early detection of DSA allows intervention that may prevent development of autoimmunity, which may help to delay or prevent BOS.

Lung Transplantation

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