January 28, 2013

Angiotensin II Blockade in Kidney Transplant Recipients


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

ACE-inhibitors and ARBs are a mainstay of treatment for patients with glomerular renal disease or proteinuria. In this randomized controlled trial, patients receiving a renal transplant were randomized to losartan or placebo. There was no difference in the primary endpoint, which was a composite of doubling of interstitial fibrosis on renal biopsy at five years or ESRD due to interstitial fibrosis. This trial shows the safety of ACE-inhibitors or ARBs in transplantation, but argues that blood pressure control per se is more important than the use of a particular class of agent.

Renal Transplantation

Tags: , , , , , ,