July 7, 2013

Anti-reflux surgery for lung transplant recipients in the presence of impedance-detected duodenogastroesophageal reflux and bronchiolitis obliterans syndrome: A study of efficacy and safety


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Bronchiolitis obliterans syndrome (BOS) has been linked to aspiration of gastric refluxate, thought to trigger an inflammatory process. This retrospective study aimed to determine the safety of anti-reflux surgery in lung transplant recipients and also to assess its effect on lung function. Forty lung transplant recipients with histologic evidence of gastroesophatgeal reflux aspiration on lung biopsies or a positive impedance study with symptomatic reflux or a consistent decline in lung function underwent laparoscopic Nissen fundoplication. The rate of decline in lung function improved in these patients, and the rates of morbidity and mortality by 30 days was minimal (2.5% and 0%).

Lung Transplantation

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