February 23, 2012

Association between donor-specific antibodies and acute rejection and resolution in small bowel and multivisceral transplantation.


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Antibody mediated rejection (AMR) is a well described phenomenon in kidney and heart transplant but its presence and impact on intestinal transplantation is unclear. AMR might contribute to the severity and relatively high rate of steroid resistant acute rejection in intestinal transplantation. This prospective study measured and correlated donor specific antibodies (DSA) levels to episodes of clinical rejection. Patients with positive DSA experienced higher rejection rate and more episodes of severe rejections. Monitoring of DSA and treatment of AMR when indicated might improve rejection outcome in intestine transplant recipients.

Liver Transplantation

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