February 8, 2011

C1q-Fixing Human Leukocyte Antigen Antibodies Are Specific for Predicting Transplant Glomerulopathy and Late Graft Failure After Kidney Transplantation


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Detection of donor-specific anti-HLA antibodies by flow cytometry of antigen-coated beads is more sensitive than the older complement-dependent cytotoxicity test performed on lymphocytes. However, flow cytometry cannot distinguish between antibodies that can fix complement or not, which may be an important marker in determining whether or not an antibody will cause antibody-mediated rejection.  In this retrospective study, the development of donor-specific antibodies that can fix the complement component C1q was associated with a high risk of transplant glomerulopathy.
Renal Transplantation