February 23, 2012

Calcineurin inhibitor minimization using sirolimus leads to improved renal function in pediatric heart transplant recipients.


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The use of calcineurin inhibitors (CNI) as part of the immunosuppressive regime following transplantation is associated with an increased risk of renal dysfunction. There are a limited number of reports on the role CNI minimization for renal recovery following pediatric heart transplant. These authors describe their experience with sirolimus and low dose cyclosporine in those patients who developed renal insufficiency. This single center study demonstrated that CNI minimization can improve renal function, with a favorable side effect profile and no increased risk of rejection. These findings are encouraging but need to be further study in a larger prospective trial.

Cardiac Transplantation

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