October 30, 2012

Calcineurin Inhibitor Sparing With Mycophenolate Mofetil in Liver Transplantion: A Systematic Review of Randomized Controlled Trials


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Chronic kidney disease is a significant complication after liver transplantation. A common strategy is to add mycophenolic acid (MPA) in order to reduce or eliminate calcineurin inhibitors (CnI). Although this is a common practice, the authors were only able to find 8 randomized controlled trials assessing its effects. Use of MPA does improve renal function, likely be allowing the dose of CnI to be reduced. However, elimination of CnI results in an increased risk of acute rejection.

Liver Transplantation, Renal Transplantation

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