July 4, 2011

Calculated PRA: initial results show benefits for sensitized patients and a reduction in positive crossmatches


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Panel reactive antibody (PRA) has been the common measure of sensitization for transplant patients that estimates the likelihood of finding a crossmatch-compatible donor. However, estimates using class I or class II PRA values makes it difficult to estimate the actual probability of finding a suitable donor. The calculated PRA (CPRA) is a readout of unacceptable HLA antigens (Class I and II combined) to which the patient has been sensitized. This report describes the impact that the CPRA has had on kidney allocation since it replaced peak and current PRA values to award sensitization points. At only 6 months since being implemented, dramatic changes are already evident including reductions in the number of kidney offers declined due to a positive crossmatch and increased percentage of transplants given to broadly sensitized patients.

Renal Transplantation

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