In the following study, researchers sought to document the frequency of care complexity in liver transplant candidates, and its association with mood disturbance and poor health-related quality of life (HRQoL). Patients from three European hospitals, were assessed for early bio-psychosocial health risks and needs (INTERMED tool), and with the Hospital Anxiety and Depression Scale (HADS). HRQoL was documented with the EuroQol and the SF36. 60 patients (75.9%) completed the protocol and 38.3% of them were identified as “complex” by INTERMED, but significant between-center differences were found. Authors go on to describe case complexity, and the variety of patient status domain such as mood disturbances and HRQoL.