Archive for the ‘Cardiac Transplantation’ Category

October 6, 2013

The Registry of the International Society for Heart and Lung Transplantation: Thirtieth Official Adult Heart Transplant Report—2013; Focus Theme: Age


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The 30th adult heart transplant ISHLT report is based on data submitted on 110,486 heart transplants in recipients of all ages (including 99,008 adults) by 407 centers worldwide since 1982 through June 30, 2012, with follow-up until June 30, 2012.

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October 6, 2013

Ten Year Experience with Extended Criteria Cardiac Transplantation


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Given the limitation of donor hearts, extended criteria cardiac transplantation (ECCT) strategies have been formally adopted at a number of transplant centers. The premise of ECCT is to match patients who fall outside traditional listing criteria (such as age 65 or older or significant co-morbidities including significant renal insufficiency, peripheral arterial disease including carotid artery […]

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September 10, 2013

Should Eligibility for Heart Transplantation Be a Requirement for Left Ventricular Assist Device Use? Recommendations Based on a Systematic Review


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This Canadian group has generated the first systematic review of the clinical and economic effects of continuous-flow LVADs in Bridge to Transplant (BTT) and Destination Therapy (DT) patients. They conclude that evidence is sufficient to support LVAD use, regardless of transplantation eligibility status, as long as patients are carefully selected and program infrastructure and budget […]

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September 9, 2013

Is it time for a cardiac allocation score? First results from the Eurotransplant pilot study on a survival benefit based heart allocation


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The Eurotransplant group demonstrated mortality on the waitlist could be predicted for non-VAD critically ill (high urgency or urgent request) patients using the Heart Failure Survival Score (HFSS) and the Seattle Heart Failure Model (SHFM). The Index for Mortality Prediction After Cardiac Transplantation (IMPACT) score was successful for predicting mortality post transplant in non-VAD patients. […]

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September 8, 2013

The urgent priority for transplantation is to trim the waiting list


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This thought provoking editorial by Dr. Lynne Warner Stevenson provides commentary on ineffective waitlist strategies and the need for change.

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September 7, 2013

Heart transplantation outcomes from cardiac arrest-resuscitated donors.


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CPR requiring donors, utilized and identified in the UNOS database tended to be younger and had a mean CPR time of 20 minutes. Despite resucitation times, use of carefully selected donors requiring CPR did not impact recipient outcomes including patient and graft survival. The authors hypothesize that ischemic preconditioning may influence the non-inferior outcomes.

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September 2, 2013

Influence of Race/Ethnic Differences in Pre-Transplant Panel Reactive Antibody on Outcomes in Heart Transplant Recipients.


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Racial and ethnic differences in long-term survival after HT are well recognized. This US study demonstrated that after adjusting for BMI, blood type, sensitization, presence of VAD at transplant, and region, both Black and Hispanic race/ethnicity ( β=0.046, p

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July 11, 2013

HeartWare ventricular assist system for bridge to transplant: Combined results of the bridge to transplant and continued access protocol trial.


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The pivotal ADVANCE Clinical Trial was a multicenter clinical trial to evaluate the HeartWare HVAD System for BTT in patients with advanced heart failure in the United States. This publication reports the analysis of combined data from the 140 BTT patients plus 192 patients from the continued access protocol (CAP) who were monitored to outcome […]

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July 10, 2013

A cardioprotective preservation strategy employing ex vivo heart perfusion facilitates successful transplant of donor hearts after cardiocirculatory death.


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Various techniques are being explored to optimize hearts and the assess organ function before transplantation. This may ultimately increase the number of organs available for transplantation. In this experimental model of DCD, an ex vivo heart perfusion strategy using initial reperfusion with a tepid adenosine-lidocaine cardioplegia and continuous myocardial perfusion minimized myocardial injury and improved […]

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July 9, 2013

Prophylactic implantable cardioverter defibrillator treatment in patients with end-stage heart failure awaiting heart transplantation.


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This observational study supports the CCS recommendations of ICD consideration in transplant eligible patients. In this study, ICDs appear to be associated with a reduction in all-cause mortality in both primary and secondary prevention compared to those without an ICD despite a median time on the waiting list of only 8 months (estimated 1-year: 88±3% vs […]

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