Archive for the ‘Cardiac Transplantation’ Category

June 21, 2013

Health-related quality of life and perceived need for mental health services in adolescent solid organ transplant recipients.


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The purpose of the following investigation was to assess interest in mental health services among parents of adolescent solid organ transplant recipients and the relationship between parent perceived need for mental health services and patient health-related quality of life (HRQOL). Sixty-three parents rated interest in receiving 10 mental health services, and patient HRQOL ratings were […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation
June 21, 2013

Advanced Therapies for Congenital Heart Disease: Ventricular Assist Devices and Heart Transplantation.


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This article reviews heart transplant and mechanical circulatory support approaches and outcomes in the management of congenital heart disease; a growing demographic in the adult heart transplant community.

No Comments Posted in Cardiac Transplantation
June 21, 2013

Cost-Effectiveness of Ventricular Assist Device Therapy as a Bridge to Transplant in Comparison to Non-Bridged Cardiac Recipients.


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This article provides contemporary Canadian data for the cost-effectiveness of BTT-VAD versus unbridged HTx recipients. The sensitivity analysis estimated a 59%, 54% and 43% chance of BTT-VAD therapy being cost-effective for high, medium and low risk patients at a willingness to pay of $100,000/LY.

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June 21, 2013

Everolimus versus mycophenolate mofetil in heart transplantation: a randomized, multicenter trial.


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This multicenter trial randomized de novo heart transplant recipients to everolimus 1.5 mg or 3.0 mg with reduced-dose cyclosporine, or mycophenolate mofetil (MMF) 3 g/day with standard-dose cyclosporine (plus corticosteroids ± induction). Primary efficacy endpoint was the 12-month composite incidence of biopsy-proven acute rejection, acute rejection associated with hemodynamic compromise, graft loss/retransplant, death or loss […]

No Comments Posted in Cardiac Transplantation
June 21, 2013

Everolimus immunosuppression in de novo heart transplant recipients: What does the evidence tell us now?


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This review article analyzes the currently available data supporting the use of everolimus in de novo heart transplant patients. Rejection, renal function, malignancy, infection and wound complications including pleural and pericardial effusions are examined. The evidence suggests that the most convincing reasons for use of everolimus are to slow the progression of CAV and to […]

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June 21, 2013

Simultaneous Thoracic and Abdominal Transplantation: Can We Justify Two Organs for One Recipient?


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This paper reviews the outcomes documented in the UNOS database for recipients of simulataneous thoracic and abdominal transplants. An interesting ethical discussion concludes the article.

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation
June 21, 2013

Time course of acquired von Willebrand disease associated with two types of continuous-flow left ventricular assist devices: HeartMate II and CircuLite Synergy Pocket Micro-pump


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The risk of bleeding complications including gastrointestinal bleeding are well documented in the VAD population. In this prospective study, acquired von Willebrand disease was confirmed to occur immediately after the implantation of both types of mechanical circulatory support and persisted up to 12 months. This phenomenon was also demonstrated in the partial support device. A […]

No Comments Posted in Cardiac Transplantation
June 21, 2013

Characterization of 25+ year survivors of cardiac transplantation


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This single center study reviews the echocardiographic, hemodynamic and clinical characteristics of long-term survivors post heart transplant. The investigators demonstrated a significant burden of cardiac allograft vasculopathy in the setting of preserved graft function. Diastolic parameters were significantly altered.

No Comments Posted in Cardiac Transplantation
June 21, 2013

Long-term outcome in patients treated with combined heart and liver transplantation for familial amyloidotic cardiomyopathy


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Currently, adults with congenital heart disease account for 3% of heart and nearly 40% of heart_lung transplant recipients worldwide. Ten years of patient outcomes were reviewed between 2001 and 2011. This single center, high volume center demonstrated comparable early and mid-term outcomes in adult congenital heart patients to general outcomes when careful recipient selection was […]

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June 21, 2013

A Prospective, Multicenter Study of Ventricular Assist Device Infections


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This prospective study demonstrated that the incidence of ventricular assist device related infection continues to burden approximately 20% of implanted patients in the era of smaller continuous flow devices. There was an associated increase in one year mortality.

No Comments Posted in Cardiac Transplantation