Archive for the ‘Lung Transplantation’ Category

October 7, 2013

Acute antibody-mediated rejection after lung transplantation


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There is no consensus on the characteristic features of antibody-mediated rejection (AMR) in lung transplantation. This retrospective cohort study characterized the clinical and pathological features of acute AMR after lung transplantation. Twenty-one patients were identified based on the presence of circulating donor-specific antibodies, histologic evidence of acute lung injury, C4d deposition, and clinical allograft dysfunction.

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October 7, 2013

Experience of extracorporeal membrane oxygenation as a bridge to lung transplantation in France


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Extracorporeal membrane oxygenation (ECMO) used as a bridge to lung transplantation in patients failing other means of life support has been disappointing, although many transplant centres continue to explore this technology for this indication. This retrospective multi centre study describes the experience 36 patients in France between 2007 and 2011.

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October 7, 2013

Lung transplantation after lung volume reduction surgery


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This retrospective cohort study aimed to describe a single centre’s experience with bilateral lung transplantations in patients with previous lung volume reduction surgery. Five-year survival was not different between the cohorts, although the incidence of both post-operative bleeding requiring re-exploration and renal dysfunction requiring dialysis were higher in the lung volume reduction group. Post-transplant peak […]

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October 7, 2013

Single-lung transplantation can be performed with acceptable outcomes using selected donors with heavy smoking history


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A shortage of organ donors can prompts centres to use suboptimal donors. This review of the UNOS database determined that adult single-lung transplantations performed with lungs from heavy smoking donors (>20 pack years) have worse outcomes when compared to transplants from standard donors, including longer length of stay and lower peak FEV1 after transplant. Higher […]

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July 8, 2013

Pulmonary rehabilitation in lung transplant candidates


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Although patients often participate in exercise training or rehabilitation prior to undergoing lung transplantation, the impact of pulmonary rehabilitation prior to lung transplantation has not been widely studied. This retrospective study described a pulmonary rehabilitation program designed for patients awaiting lung transplantation, assessed the exercise capacity, training volumes, and health related quality of life in […]

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July 7, 2013

Anti-reflux surgery for lung transplant recipients in the presence of impedance-detected duodenogastroesophageal reflux and bronchiolitis obliterans syndrome: A study of efficacy and safety


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Bronchiolitis obliterans syndrome (BOS) has been linked to aspiration of gastric refluxate, thought to trigger an inflammatory process. This retrospective study aimed to determine the safety of anti-reflux surgery in lung transplant recipients and also to assess its effect on lung function. Forty lung transplant recipients with histologic evidence of gastroesophatgeal reflux aspiration on lung […]

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July 6, 2013

Impact of nutritional state on lung transplant outcomes


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The impact of poor nutritional status on post lung transplantation outcomes is not clear, with previous studies showing conflicting impact on post operative complications and survival. This single centre retrospective study analyzed the association between markers of nutritional status (body mass index, weight/height ratio, serum albumin, total protein, immunoglobulins, and absolute lymphocyte count) and post […]

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July 5, 2013

Disparities in lung transplantation before and after introduction of the lung allocation score


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The lung allocation score (LAS) was implemented in the USA in 2005 to ensure a more objective process for allocation of donor lungs and to minimize the effects of geography. This study examines the association between race, gender, and lung transplantation before and after introduction of the LAS, using data from the UNOS database. In […]

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June 21, 2013

Health-related quality of life and perceived need for mental health services in adolescent solid organ transplant recipients.


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The purpose of the following investigation was to assess interest in mental health services among parents of adolescent solid organ transplant recipients and the relationship between parent perceived need for mental health services and patient health-related quality of life (HRQOL). Sixty-three parents rated interest in receiving 10 mental health services, and patient HRQOL ratings were […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation
June 21, 2013

Simultaneous Thoracic and Abdominal Transplantation: Can We Justify Two Organs for One Recipient?


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This paper reviews the outcomes documented in the UNOS database for recipients of simulataneous thoracic and abdominal transplants. An interesting ethical discussion concludes the article.

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation