Archive for the ‘Lung Transplantation’ Category

June 21, 2013

Colonization With Small Conidia Aspergillus Species Is Associated With Bronchiolitis Obliterans Syndrome: A Two-Center Validation Study


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Aspergillus colonization is common after lung transplantation. Size of conidia may be important for the virulence of Aspergillus species. Weigt et al. performed a retrospective review of 780 lung transplant patients from two U.S. centers. Patients colonized with small conidia Aspergillus (but not large conidia species) had a significantly greater risk for developing bronchiolitis obliterans […]

No Comments Posted in Lung Transplantation, Transplant Infectious Disease
June 21, 2013

Special Issue: The American Society of Transplantation Infectious Diseases Guidelines 3rd Edition


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This supplement to the American Journal of Transplantation is dedicated to transplant infectious diseases. The articles in the supplement are guidelines for various pathogens and infectious syndromes that affect transplant recipients. This is the 3rd edition of the guidelines and updates the previous edition published in 2009. Three new chapters were added to this edition: […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation, Transplant Infectious Disease
June 21, 2013

Randomized Controlled Trial of High-Dose Intradermal Versus Standard-Dose Intramuscular Influenza Vaccine in Organ Transplant Recipients


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Influenza vaccine is recommended for transplant recipients annually. There are several types of influenza vaccines on the market now including standard intramuscular, adjuvanted intramuscular and intradermal. An advantage of giving flu vaccine intradermally is to take advantage of the abundant Langerhans/dendritic cells at the site that act as potent antigen presenting cells. Baluch et al. […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation, Transplant Infectious Disease
June 21, 2013

Optimal Testing of the Live Organ Donor for Blood-Borne Viral Pathogens: The Report of a Consensus Conference


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Transmission of infection from donor to recipient is an an inherent risk in transplantation that can likely never be completely eliminated. This is true even in living donation, where transmission of hepatitis C and HIV has been reported. This paper reports the results of a conference on this topic. Most significant is the fact that […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation, Transplant Infectious Disease, Uncategorized
June 21, 2013

Outcomes in systemic sclerosis-related lung disease after lung transplantation


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Although systemic sclerosis (SSc) causes fibrosis and small vessel vasculopathy in multiple organ systems, pulmonary disease, including interstitial lung disease and/or pulmonary hypertension, is the leading cause of death in these patients. Due to their multi-organ involvement, candidacy for lung transplantation may be controversial. In particular, esophageal dysmotility and gastroparesis may increase aspiration-induced injury to […]

No Comments Posted in Lung Transplantation
June 21, 2013

Lung transplantation for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation: a single-center experience


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This case series describes 7 patients with severe chronic graft-versus-host disease (cGvHD) associated with bronchiolitis obliterans (BO) after allogeneic hematopoietic stem cell transplantation (HCT) who underwent lung transplantation. About 20% of patients with severe cGVHD develop BO, which portends a poor prognosis. Lung transplantation may be performed for severe refractory BO. In this group, 6 […]

No Comments Posted in Lung Transplantation
June 21, 2013

Pathologic findings in lung allografts with anti-HLA antibodies


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Antibody-mediated rejection is a well recognized cause of accelerated allograft dysfunction in heart and kidney transplantation in the setting of de novo donor specific antibodies (DSA). Development of de novo DSA in lung transplant recipients has been linked with early development of bronchiolitis obliterans syndrome (BOS), although the role of antibody-mediated rejection in BOS is […]

No Comments Posted in Lung Transplantation
April 1, 2013

Impact of Consideration of Transplantation on End-of-Life Care for Patients During a Terminal Hospitalization


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The researchers of this study looked at how consideration of transplantation affects the end-of-life care received by patients. An evaluation of the care provided was undertaken by abstracting medical records for 496 adults who died in one transplant medical center between April 2005 and April 2006. The quality indicators measured were chosen from the Assessing […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation, Uncategorized
April 1, 2013

Pre-transplant malignancy: an analysis of outcomes after thoracic organ transplantation


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Using the UNOS database, this retrospective study compared survival post lung-transplantation or orthotopic heart transplantation in patients with pre-transplant malignancy (PTM) to a matched cohort without PTM. The incidence of PTM in lung transplants was 5.4% and in orthotopic heart transplants was 5.6%. No significant difference was noted in survival at 30-days, 1-year, and 5-years […]

No Comments Posted in Cardiac Transplantation, Lung Transplantation
April 1, 2013

Decline in 25% to 75% forced expiratory flow as an early predictor of chronic airway rejection in pediatric lung transplant recipients


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Early identification of bronchiolitis obliterans by non-invasive measures is desirable, which lead to the definition of bronchiolitis obliterans syndrome by decline in FEV1. This study hypothesized that a decline in FEF25-75 should occur before a decline in FEV1, allowing earlier diagnosis of bronchiolitis obliterans. Retrospective review of 31 pediatric lung transplantation recipients at a single […]

No Comments Posted in Lung Transplantation