Archive for the ‘Pancreas Transplantation’ Category

September 26, 2013

Acute Cellular and Antibody-Mediated Rejection of the Pancreas Allograft: Incidence, Risk Factors and Outcomes

Antibody-mediated pancreas transplant rejection is a relatively recently recognized entity. In this retrospective study, the rate of antibody-mediated rejection post-pancreas transplant was similar to that of acute cellular rejection. Class I DSA were more predictive of antibody-mediated rejection than class II DSA. Antibody-mediated rejection should be considered in all patients with pancreas graft dysfunction post-transplant.

No Comments Posted in Pancreas Transplantation, Renal Transplantation
June 21, 2013

Special Issue: The American Society of Transplantation Infectious Diseases Guidelines 3rd Edition


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This supplement to the American Journal of Transplantation is dedicated to transplant infectious diseases. The articles in the supplement are guidelines for various pathogens and infectious syndromes that affect transplant recipients. This is the 3rd edition of the guidelines and updates the previous edition published in 2009. Three new chapters were added to this edition: […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation, Transplant Infectious Disease
June 21, 2013

Randomized Controlled Trial of High-Dose Intradermal Versus Standard-Dose Intramuscular Influenza Vaccine in Organ Transplant Recipients


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Influenza vaccine is recommended for transplant recipients annually. There are several types of influenza vaccines on the market now including standard intramuscular, adjuvanted intramuscular and intradermal. An advantage of giving flu vaccine intradermally is to take advantage of the abundant Langerhans/dendritic cells at the site that act as potent antigen presenting cells. Baluch et al. […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation, Transplant Infectious Disease
June 21, 2013

Optimal Testing of the Live Organ Donor for Blood-Borne Viral Pathogens: The Report of a Consensus Conference


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Transmission of infection from donor to recipient is an an inherent risk in transplantation that can likely never be completely eliminated. This is true even in living donation, where transmission of hepatitis C and HIV has been reported. This paper reports the results of a conference on this topic. Most significant is the fact that […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation, Transplant Infectious Disease, Uncategorized
June 21, 2013

Transmission of Strongyloides stercoralis Through Transplantation of Solid Organs – Pennsylvania, 2012.


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Strongyloides is an intestinal nematode that is endemic in tropical areas. Most infected persons are asymptomatic. However, in immunocompromised, the infection can become disseminated and fatal. Infected organ donors can transmit Strongyloides to recipients and this has been described in the past. This report describes three organ recipients who were diagnosed with Strongyloides. Serum from […]

No Comments Posted in Liver Transplantation, Pancreas Transplantation, Renal Transplantation, Transplant Infectious Disease
April 1, 2013

Does reduction in mycophenolic acid dose compromise efficacy regardless of tacrolimus exposure level? An analysis of prospective data from the Mycophenolic Renal Transplant (MORE) Registry


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Post-transplant, mycophenolic acid (MPA) dose is frequently reduced because of side effects or toxicity. However, overall MPA levels are higher in patients on tacrolimus as opposed to cyclosporine. In this prospective study of patients who were also on tacrolimus, MPA dose reduction or discontinuation was associated with a higher risk of subsequent acute rejection. The […]

No Comments Posted in Pancreas Transplantation, Renal Transplantation
January 28, 2013

Consensus Guidelines on the Testing and Clinical Management Issues Associated With HLA and Non-HLA Antibodies in Transplantation


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Solid phase assays on the Luminex platform have become the standard for the detection and characterization of HLA antibodies. However, transplant professionals have struggled with interpretation of the highly sensitive Luminex assay with respect to cytotoxicity assays and clinical relevance. To tackle this problem The Transplantation Society asked a group of experts with extensive experience […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation
January 28, 2013

Effects of HLA-Matched Blood Transfusion for Patients Awaiting Renal Transplantation


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HLA sensitization in the pre-transplant period can limit the chances of successfully receiving a transplant. Sensitization (primarily to mismatched HLA class I) can occur as a result of blood transfusions due to the presence of platelets in each unit of blood and the small number of leukocytes that remain even in leuko-depleted blood. This study […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation
January 28, 2013

Effects of HLA-Matched Blood Transfusion for Patients Awaiting Renal Transplantation


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Preventing the development of anti-HLA antibodies is an important step in improving access to transplantation. In this non-randomized retrospective study, patients who received red blood cell transfusions from donors who were closely matched for class I antigens were less likely to develop anti-HLA antibodies than patients who received randomly selected donors. These findings are intriguing, […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation
January 28, 2013

Pancreas-After-Kidney Versus Synchronous Pancreas-Kidney Transplantation: Comparison of Intermediate-Term Results


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Most registries show worse outcomes with pancreas-after-kidney (PAK) compared to simultaneous pancreas-kidney (SPK) transplants. In this single-centre, retrospective study, living donor renal transplants followed by pancreas transplants showed comparable results to SPK, despite the long time between kidney and pancreas transplants. Greater use of PAK may shorten time of dialysis for patient with a living […]

No Comments Posted in Pancreas Transplantation, Renal Transplantation