Archive for the ‘Renal Transplantation’ Category

September 26, 2013

Complement-Binding Anti-HLA Antibodies and Kidney-Allograft Survival


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

The ability to detect anti-HLA antibodies is very sensitive and specific, but it is not clear if all antibodies are the same. Specifically, some antibodies may bind and activate complement better than others. In this retrospective study, the presence of antibodies that could fix C1q and initiate the complement cascade was associated with higher rates […]

No Comments Posted in Renal Transplantation, Uncategorized
September 1, 2013

Podocyte Effacement Closely Links to suPAR Levels at Time of Posttransplantation Focal Segmental Glomerulosclerosis Occurrence and Improves With Therapy


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

Serum soluble urokinase-type plasminogen activator receptor (suPAR) has been put forth as the a candidate for the elusive “FSGS” factor that may lead to aggressive and early recurrence post-transplant. This study of patients with recurrent FSGS post-transplant found higher suPAR levels in patients with more extensive podocyte damage on renal biopsy. However, this study is […]

No Comments Posted in Renal Transplantation
August 31, 2013

Higher Risk of Kidney Graft Failure in the Presence of Anti-Angiotensin II Type-1 Receptor Antibodies


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

While HLA antibodies are a well-recognized risk factor for graft loss, the role of non-HLA antibodies is less clear. Antibodies to angiotensin II type I receptor has been previously reported in patients with failing grafts. In this study, patients who developed anti-AT I receptor antibodies had a higher risk of graft failure over and above […]

No Comments Posted in Renal Transplantation, Uncategorized
August 30, 2013

Improving Outcomes of Renal Transplant Recipients With Behavioral Adherence Contracts: A Randomized Controlled Trial


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

Non-adherence is a well-recognized risk factor for adverse events post-transplant, but there have been few interventions aimed at improving adherence. In this randomized controlled trial, regular interaction with a pharmacist and a contract laying out behaviours required of the patient improved adherence, as measured by medication refills. It also resulted in fewer hospitalization.

No Comments Posted in Renal Transplantation, Uncategorized
August 2, 2013

Urinary-Cell mRNA Profile and Acute Cellular Rejection in Kidney Allografts


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

The gold standard fro diagnosing acute rejection remains biopsy. A non-invasive test that could reliably diagnose rejection would be an important step forward. In this study, a set of three different RNA molecules in the urine of renal transplant recipients showed a high degree of sensitivity for acute cellular rejection, and distinguished it from antibody-mediated […]

No Comments Posted in Renal Transplantation
June 21, 2013

Is there an association between immunosuppressant therapy medication adherence and depression, quality of life, and personality traits in the kidney and liver transplant population?


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

In the following study, researchers measured the association of transplant patients’ personality, depression, and quality of life with medication adherence in a cross-sectional group of kidney and liver transplant recipients greater than 1 year post-transplant.86 kidney and 50 liver transplant patients completed the surveys. Results found kidney transplant patients who exhibited “low openness” scores were […]

No Comments Posted in Liver Transplantation, Renal Transplantation
June 21, 2013

Health-related quality of life and perceived need for mental health services in adolescent solid organ transplant recipients.


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

The purpose of the following investigation was to assess interest in mental health services among parents of adolescent solid organ transplant recipients and the relationship between parent perceived need for mental health services and patient health-related quality of life (HRQOL). Sixty-three parents rated interest in receiving 10 mental health services, and patient HRQOL ratings were […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation
June 21, 2013

Phospholipase A2 Receptor (PLA2R) Staining Is Useful in the Determination of De Novo Versus Recurrent Membranous Glomerulopathy


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

The phospholipiase A2 receptor (PLA2R) has been identified as an important target in most cases of native membranous nephropathy. Distinguishing between post-transplant recurrent membranous nephropathy and de novo disease is important, In this paper, staining of renal transplant biopsies for PLA2R was found in cases with recurrent, but not de novo disease. This shows that […]

No Comments Posted in Renal Transplantation
June 21, 2013

Simultaneous Thoracic and Abdominal Transplantation: Can We Justify Two Organs for One Recipient?


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

This paper reviews the outcomes documented in the UNOS database for recipients of simulataneous thoracic and abdominal transplants. An interesting ethical discussion concludes the article.

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation
June 21, 2013

Oral Paricalcitol Reduces the Prevalence of Posttransplant Hyperparathyroidism: Results of an Open Label Randomized Trial


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

Bone disease and secondary hyperparathyroidism are common following renal transplantation. This open-label randomized controlled trial compared the calcitriol analog paricalcitol to placebo, with a primary endpoint of hyperparathyroidism at one year post-transplant. There was less hyperparathyroidism in the paricalcitol-treated group. However, there was no difference in bone density between groups. Also, these patients were not […]

No Comments Posted in Renal Transplantation