Archive for the ‘Transplant Infectious Disease’ Category

June 21, 2013

Hypocomplementemia in Kidney Transplant Recipients: Impact on the Risk of Infectious Complications


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Post-transplant, there is no ideal measure of predicting how immunosuppressed an individual recipient is. Fernandez-Ruiz et al. assessed complement (C3 and C4) levels at 0,1,6 months post-kidney transplant in 270 patients. Those with C3 hypocomplementemia at month 1 had greater incidences of overall infection, bacterial infection and fungal infection up to month 6 post-transplant. This […]

No Comments Posted in Renal Transplantation, Transplant Infectious Disease
June 21, 2013

Donor and Recipient BKV-Specific IgG Antibody and Posttransplantation BKV Infection: A Prospective Single-Center Study


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BK nephropathy is an important cause of graft failure. Similar to other viruses, it is possible that BK donor and recipient serology screening could be used to risk stratify patients. Sood et al. performed BK serology on 192 adult and 11 pediatric donor and recipient pairs. Recipients also underwent BK surveillance. They divided patients into […]

No Comments Posted in Renal Transplantation, Transplant Infectious Disease
June 21, 2013

Colonization With Small Conidia Aspergillus Species Is Associated With Bronchiolitis Obliterans Syndrome: A Two-Center Validation Study


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Aspergillus colonization is common after lung transplantation. Size of conidia may be important for the virulence of Aspergillus species. Weigt et al. performed a retrospective review of 780 lung transplant patients from two U.S. centers. Patients colonized with small conidia Aspergillus (but not large conidia species) had a significantly greater risk for developing bronchiolitis obliterans […]

No Comments Posted in Lung Transplantation, Transplant Infectious Disease
June 21, 2013

Subclinical Epstein_Barr Virus Viremia Among Adult Renal Transplant Recipients: Incidence and Consequences


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EBV viremia occurs frequently after transplantation and can be related to post-transplant lymphoproliferative disorders (PTLD). However, the consequences of the majority of viremia are unclear. Barnoulid et al. followed EBV viral loads in 383 kidney transplant patients during the first year post-transplant. 40% of patients had at least one detected viremia; viremia was more common […]

No Comments Posted in Renal Transplantation, Transplant Infectious Disease
June 21, 2013

Screening for BK Viremia Reduces But Does Not Eliminate the Risk of BK Nephropathy: A Single-Center Retrospective Analysis


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BK nephropathy is an important cause of graft loss and the majority of kidney transplant centers perform plasma BK virus screening. The purpose of screening is to detect virus early so that pre-emptive measures such as reduction of immunosuppression can be employed, thereby preventing progression to nephropathy. Knight et al. reviewed 369 kidney transplant recipients […]

No Comments Posted in Renal Transplantation, Transplant Infectious Disease
June 21, 2013

Special Issue: The American Society of Transplantation Infectious Diseases Guidelines 3rd Edition


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This supplement to the American Journal of Transplantation is dedicated to transplant infectious diseases. The articles in the supplement are guidelines for various pathogens and infectious syndromes that affect transplant recipients. This is the 3rd edition of the guidelines and updates the previous edition published in 2009. Three new chapters were added to this edition: […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation, Transplant Infectious Disease
June 21, 2013

Impact of aerosolized ribavirin on mortality in 280 allogeneic haematopoietic stem cell transplant recipients with respiratory syncytial virus infections.


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In both HSCT and SOT (especially lung transplants), RSV infections carry a high risk of morbidity and mortality. Ribavirin has been used for the treatment of RSV; however, it is unclear whether ribavirin is best given orally, intravenously, or by aerosolization. Aerosolized ribavirin is teratogenic and requires administration in a negative pressure room. Therefore, many […]

No Comments Posted in Transplant Infectious Disease
June 21, 2013

Randomized Controlled Trial of High-Dose Intradermal Versus Standard-Dose Intramuscular Influenza Vaccine in Organ Transplant Recipients


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Influenza vaccine is recommended for transplant recipients annually. There are several types of influenza vaccines on the market now including standard intramuscular, adjuvanted intramuscular and intradermal. An advantage of giving flu vaccine intradermally is to take advantage of the abundant Langerhans/dendritic cells at the site that act as potent antigen presenting cells. Baluch et al. […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation, Transplant Infectious Disease
June 21, 2013

Optimal Testing of the Live Organ Donor for Blood-Borne Viral Pathogens: The Report of a Consensus Conference


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Transmission of infection from donor to recipient is an an inherent risk in transplantation that can likely never be completely eliminated. This is true even in living donation, where transmission of hepatitis C and HIV has been reported. This paper reports the results of a conference on this topic. Most significant is the fact that […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation, Transplant Infectious Disease, Uncategorized
June 21, 2013

Transmission of Strongyloides stercoralis Through Transplantation of Solid Organs – Pennsylvania, 2012.


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Strongyloides is an intestinal nematode that is endemic in tropical areas. Most infected persons are asymptomatic. However, in immunocompromised, the infection can become disseminated and fatal. Infected organ donors can transmit Strongyloides to recipients and this has been described in the past. This report describes three organ recipients who were diagnosed with Strongyloides. Serum from […]

No Comments Posted in Liver Transplantation, Pancreas Transplantation, Renal Transplantation, Transplant Infectious Disease