Archive for the ‘Uncategorized’ Category

November 28, 2013

Class II HLA Epitope Matching—A Strategy to Minimize De Novo Donor-Specific Antibody Development and Improve Outcomes


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Although testing for HLA antibodies is long-established practice in transplantation, the immune system actually makes antibodies against specific epitopes, not antigens. This study used the HLA Matchmaker program to assess whether the degree of epitope mismatching predicted the development of post-transplant class II donor-specific antibodies. Thresholds for epitope mismatching at DR and DQ were found. […]

No Comments Posted in Renal Transplantation, Uncategorized
September 26, 2013

Improving Outcomes of Renal Transplant Recipients With Behavioral Adherence Contracts: A Randomized Controlled Trial


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Non-adherence is a well-recognized cause of poor outcomes post-transplant, but effective interventions to address this problem have been rare. In this randomized controlled trial, patients who were at least one year post-transplant and developed an adherence contract with a pharmacist had better medication adherence, as measured by prescription refills. The rate of hospitalizations was also […]

No Comments Posted in Renal Transplantation, Uncategorized
September 26, 2013

Complement-Binding Anti-HLA Antibodies and Kidney-Allograft Survival


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The ability to detect anti-HLA antibodies is very sensitive and specific, but it is not clear if all antibodies are the same. Specifically, some antibodies may bind and activate complement better than others. In this retrospective study, the presence of antibodies that could fix C1q and initiate the complement cascade was associated with higher rates […]

No Comments Posted in Renal Transplantation, Uncategorized
August 31, 2013

Higher Risk of Kidney Graft Failure in the Presence of Anti-Angiotensin II Type-1 Receptor Antibodies


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While HLA antibodies are a well-recognized risk factor for graft loss, the role of non-HLA antibodies is less clear. Antibodies to angiotensin II type I receptor has been previously reported in patients with failing grafts. In this study, patients who developed anti-AT I receptor antibodies had a higher risk of graft failure over and above […]

No Comments Posted in Renal Transplantation, Uncategorized
August 30, 2013

Improving Outcomes of Renal Transplant Recipients With Behavioral Adherence Contracts: A Randomized Controlled Trial


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Non-adherence is a well-recognized risk factor for adverse events post-transplant, but there have been few interventions aimed at improving adherence. In this randomized controlled trial, regular interaction with a pharmacist and a contract laying out behaviours required of the patient improved adherence, as measured by medication refills. It also resulted in fewer hospitalization.

No Comments Posted in Renal Transplantation, Uncategorized
June 21, 2013

Optimal Testing of the Live Organ Donor for Blood-Borne Viral Pathogens: The Report of a Consensus Conference


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Transmission of infection from donor to recipient is an an inherent risk in transplantation that can likely never be completely eliminated. This is true even in living donation, where transmission of hepatitis C and HIV has been reported. This paper reports the results of a conference on this topic. Most significant is the fact that […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation, Transplant Infectious Disease, Uncategorized
April 1, 2013

Impact of Consideration of Transplantation on End-of-Life Care for Patients During a Terminal Hospitalization


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The researchers of this study looked at how consideration of transplantation affects the end-of-life care received by patients. An evaluation of the care provided was undertaken by abstracting medical records for 496 adults who died in one transplant medical center between April 2005 and April 2006. The quality indicators measured were chosen from the Assessing […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation, Uncategorized
September 19, 2012

The Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT): a new tool for the psychosocial evaluation of pre-transplant candidates.


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In this study, researchers developed and tested a new pre-transpalnt psychosocial assessment tool:the Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT). Five examiners blindly applied the SIPAT to 102 randomly selected transplant cases, including liver, heart, and lung patients. SIPAT scores were found to be highly predictive of the transplant psychosocial outcome. The authors concluded that […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Uncategorized
November 18, 2011

Guidelines for the diagnosis of antibody-mediated rejection in pancreas allografts-updated Banff grading schema


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The Banff consensus, originally developed as a histopathological guideline to diagnoses in transplanted kidneys, has been adopted by other transplanted organs. Pancreas transplant specialists developed and implemented their first set of guidelines in 2008 with much of the detail pertaining to T-cell-mediated rejection. This latest set of guidelines now addresses the criteria proposed for the […]

No Comments Posted in Uncategorized