July 9, 2012

Changes in serial B-type natriuretic peptide level independently predict cardiac allograft rejection


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Graft rejection remains the main limiting factor in longevity following heart transplantation. Invasive endomyocardial biopsy (EMBx) remains the gold standard in screening for rejection. Biomarkers pose a less invasive and readily available adjunct screening modality for rejection. In the future it may be feasible to utilize biomarkers to select patients whom may benefit from immediate therapy for suspected acute cardiac allograft rejection and from EMBx, limiting the need for scheduled invasive screenings. In this single-center, prospective study, the authors report on the utility of BNP as an independent predictor of moderate/serious cardiac allograft rejection.

Cardiac Transplantation

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