February 23, 2012

Characterization and outcomes of young infants with acute liver failure


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Acute liver failure in children (PALF) is a dramatic and sometimes fatal clinical syndrome in which previously healthy children rapidly lose hepatic function and become critically ill within days to weeks, and decision-making to predict the natural history is complex.  The causes of PALF are age-dependent, with young infants presenting particularly unique diagnostic considerations, with differences in etiologies and outcomes.  The relative rarity of this condition has precluded accumulation of a large amount of comprehensive experience in the published literature, which is currently comprised of primarily single-center experiences over typically a wide time period.  This study characterizes infants who are under the age of 90 days at time of enrollment into the PALF consortium, an international, prospective registry of children presenting with acute liver failure.

Liver Transplantation

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