April 14, 2012

Clinical and radiological features of respiratory syncytial virus in solid organ transplant recipients: a single-center experience


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Respiratory syncytial virus (RSV) infection is well known to cause serious pulmonary infections in hematopoietic stem cell transplant recipients, but the effect of this virus in solid organ transplant recipients is less understood. This retrospective review identified 24 patients within 3 years who developed RSV infection, 50% of who were solid organ transplant recipients (5 renal, 4 liver, 3 lung recipients). The most common clinical presentations in SOT recipients were fever (42%), cough (42%), and dyspnea (33%). Chest radiograph findings included consolidation, diffuse interstitial opacities, pleural effusions, and normal films. No co-infections were identified. One lung transplant patient had an episode of acute rejection at the time of RSV infection. Treatment with ribavirin was variable. No patients died as a complication of RSV infection. This descriptive study suggests RSV infection is not as risky in SOT recipients vs. HSCT patients, but more prevalent than in the general population.

Lung Transplantation

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