July 5, 2009

Clinical Relevance of Pretransplant Donor-Specific HLA Antibodies Detected by Single-Antigen Flow-Beads.


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Single antigen flow beads is the most sensitive method currently available to detect the presence of anti-HLA antibodies. In this retrospective single-centre study, the presence of donor-specific antibodies (DSA) at the time of transplant was associated with a significantly increased risk of antibody-mediated rejection, despite a negative crossmatch by the AHG-CDC technique for both T and B cells. However, for unknown reasons all patients with DSA had antibody-mediated rejection.

Renal Transplantation