April 14, 2012

Cyclosporine lowering with everolimus versus mycophenolate mofetil in heart transplant recipients: Long-term follow-up of the SHIRAKISS randomized, prospective study.


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

This publication reveals long-term follow-up of 34 patients initially randomized to a study exploring two different cyclosporine-lowering approaches in reducing the progression of renal dysfunction in heart transplant recipients.  Cyclosporine trough levels remained stable in both arms and were significantly lower in the everolimus arm at all time-points. Proteinuria increased significantly during the first 12 months of treatment in everolimus patients but this everolimus-induced proteinuria did not affect changes in CrCl at either the 12-month or 3-year time-points.

Cardiac Transplantation

Tags: , , , ,