August 14, 2011

De Novo Anti-HLA Antibody After Pandemic H1N1 and Seasonal Influenza Immunization in Kidney Transplant Recipients


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Factors that lead to the development of de novo HLA antibodies or increase the strength of HLA antibodies in sensitized patients are incompletely understood. Transplant recipients are recommended to receive annual influenza immunization due to the high risk of complications in these patients. This study examined the effect of the new H1N1 influenza vaccine developed in 2009 on the generation of de novo HLA antibodies in kidney transplant patients. HLA antibodies were assessed prior to, six weeks, and six months after vaccination. Between the two cohorts examined, HLA antibodies developed in 17.3% and 11.9%, significantly higher than the 6.1% found in historical controls. In total, 13 patients developed donor specific antibodies but the antibody levels were low and most were below detection after six months. The study does not argue against influenza vaccination in transplant recipients but does suggest attentive monitoring of these patients following vaccinations using a similar type of adjuvant. See also here and here.

 

Renal Transplantation

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