April 1, 2013

Decline in 25% to 75% forced expiratory flow as an early predictor of chronic airway rejection in pediatric lung transplant recipients


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Early identification of bronchiolitis obliterans by non-invasive measures is desirable, which lead to the definition of bronchiolitis obliterans syndrome by decline in FEV1. This study hypothesized that a decline in FEF25-75 should occur before a decline in FEV1, allowing earlier diagnosis of bronchiolitis obliterans. Retrospective review of 31 pediatric lung transplantation recipients at a single centre identified 11 patients with bronchiolitis obliterans syndrome. For these patients, FEF 25-75 declined by 20% an average of 168 days earlier than the decline in FEV1. The sensitivity of FEF25-75 for BOS was 100% and specificity was 90%.

Lung Transplantation

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