October 30, 2012

Diagnosis and Management of Tuberculosis in Transplant Donors: A Donor-Derived Infections Consensus Conference Report(†).


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Mycobacterium tuberculosis is a world-wide problem and has become one of the most common bacterial causes of donor-derived infections after organ transplant. This paper presents the report of a consensus conference that took place in 2010. The consensus, which is endorsed by the American Society of Transplantation as well as the Canadian Society of Transplantation, reported on screening, diagnosis, and prevention of donor-derived TB. Recommendations were developed for screening of both living and deceased donors. The consensus also took into account the differences in the burden of TB disease in Canada/U.S. versus South American or European countries. The report states that donors with active TB should generally not be used and also presents potential management of donors that have latent TB. The consensus recommendations are welcomed given lack of data on the subject and a wide variety of practices especially when donors are suspected to have latent TB infection.

Transplant Infectious Disease

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