June 21, 2013

Donor and Recipient BKV-Specific IgG Antibody and Posttransplantation BKV Infection: A Prospective Single-Center Study


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BK nephropathy is an important cause of graft failure. Similar to other viruses, it is possible that BK donor and recipient serology screening could be used to risk stratify patients. Sood et al. performed BK serology on 192 adult and 11 pediatric donor and recipient pairs. Recipients also underwent BK surveillance. They divided patients into BK D+/R-, D+/R+, D-/R+ and D-/R-. In the BK D+/R- group, any viremia and significant viremia (>=10,000 copies/mL) was significantly higher than in the other groups. In pediatrics, the only BK infections seen were in the D+/R- group. Currently BK serology is not generally available in standard clinical laboratories and is not routinely performed on donors or recipients. However, this study shows that serology could potentially predict risk and be combined with monitoring for viremia.

Renal Transplantation, Transplant Infectious Disease

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