July 4, 2011

Donor-Directed MHC Class I Antibody Is Preferentially Cleared from Sensitized Recipients of Combined Liver/Kidney Transplants


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Although simultaneous liver and kidney transplantation (SLKT) is uncommon, the liver’s ability to resist hyperacute antibody mediated rejection (AbMR) may allow the transplant to succeed despite the presence of pre-existing donor specific antibody (DSA). However, the long term impact of pre-existing DSA in SLKT is incompletely understood. This study analyzed a small cohort of SLKT recipients with pre-existing DSA (n=6). Although class I DSA levels dramatically decreased post-transplant, class II DSA levels were only moderately affected. Despite the small study size, it highlights an important difference in a liver allograft’s ability to absorb DSA with particular interest given the damaging long-term effects of class II DSA on kidneys and as recently described for livers.

Liver Transplantation, Renal Transplantation

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