October 30, 2012

Donor-Specific Antibodies after Ceasing Immunosuppressive Therapy, with or without an Allograft Nephrectomy


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The best strategy to manage patients with a failed renal allograft is unknown. It is unknown whether the allograft acts a “sponge” for DSA, and removal may lead to higher levels of anti-HLA antibodies. This study compared patients whose immunosuppression stopped, and who either underwent a graft nephrectomy or not. Allograft nephrectomy resulted in a higher likelihood of detection of DSA.

Renal Transplantation

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