January 28, 2013

Effects of HLA-Matched Blood Transfusion for Patients Awaiting Renal Transplantation


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

HLA sensitization in the pre-transplant period can limit the chances of successfully receiving a transplant. Sensitization (primarily to mismatched HLA class I) can occur as a result of blood transfusions due to the presence of platelets in each unit of blood and the small number of leukocytes that remain even in leuko-depleted blood. This study compared the effects of transfusing renal transplant patients with HLA class I-matched (HLA-A and –B) blood to those receiving unmatched blood. None of the patients receiving HLA-selected units showed a change in HLA antibody levels whereas 7/31 patients who received unmatched units demonstrated changes in antibody levels: 3 de novo HLA antibodies and 4 with an increase >20% in PRA. Thus the use of HLA-typed blood decreases the risk of developing HLA antibody in the pre-transplant period and may be an option to pursue for transplant recipients of all types of solid organ transplants.

Cardiac Transplantation, Intestinal Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation

Tags: ,