October 30, 2012

Emergence of Aspergillus calidoustus Infection in the Era of Posttransplantation Azole Prophylaxis.


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

Invasive aspergillosis is an important cause of morbidity after lung transplant. The majority of lung transplant centers use universal anti-mould prophylaxis for 3-6 months after transplant. This may be extended further depending on the patient’s level of immunosuppression. Resistant fungi can emerge with such prolonged prophylaxis. This paper reports a series of lung transplant patients that had pulmonary infections with a rare fungus, Aspergillus calidoustus. This Aspergillus species tends to be resistant to azoles. The authors found that although the rates of Aspergillus fumigatus had decreased with universal azole use, this azole-resistant fungus was increasing found in their population. In a case-control study, duration of voriconazole exposure was a significant factor in those that had this unusual species. Therefore, benefits of universal azole use must be balanced by the risk of unusual fungi.

Transplant Infectious Disease

Tags: , , ,