January 28, 2013

Epidemiology, Clinical Characteristics and Outcomes of Extensively Drug-Resistant Acinetobacter baumannii Infections among Solid Organ Transplant Recipients.


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Acinetobacter is an important nosocomial pathogen. Extensively drug resistant Acinetobacter is generally only sensitive to colistin and tigecycline. The authors performed a retrospective study of SOT recipients over a 5 year period, that were colonized or infected with extensively drug resistant Acinetobacter to determine outcomes. 69 patients were included, most of whom had ventilator-associated pneumonia. In those who were infected (59%), the 28-day survival rate was 54%. The optimal treatment regimen for such difficult infections is unknown. The authors used a combination of carbapenem and colistin and this was an independent predictor of clinical success. However, colistin resistance also occurred while on treatment.

Transplant Infectious Disease

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