January 28, 2013

Epidemiology, risk factors, and outcomes of Clostridium difficile infection in kidney transplant recipients.


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Clostridium difficile infections cause morbidity and mortality. The authors conducted a retrospective review of Clostridium difficile infection (CDI) in kidney transplant recipients at their center over a 3 year period. The overall rate of CDI was 6.1% and increased over time during the study. A case-control study was subsequently performed to determine the risk factors for infection. Independent predictors of CDI among kidney transplant recipients were VRE colonization, having a CDC-criteria high risk donor, and administration of high-risk antibiotics such as antipseudomonal penicillins and carbapenems. There were no deaths in this series although 10.8% had recurrent infection. The study highlights the need for judicious antibiotic use and good infection control practices in transplant units.

Transplant Infectious Disease

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