December 26, 2010

Fibrosis with Inflammation at One Year Predicts Transplant Functional Decline


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Interstitial fibrosis is commonly seen in renal transplant biopsies as early as three months post-transplant. More concerning is the finding of fibrosis along with subclinical inflammation, i.e. inflammation found on a protocol biopsy not accompanied by a rise in serum creatinine. This cohort study with up to five years of follow-up shows that the combination of fibrosis and subclinical inflammation is associated with a decline in GFR and lower graft survival.
Free full text kindly provided by ASN.
Renal Transplantation