January 28, 2013

High-sensitive Troponin T measurements early after heart transplantation predict short- and long-term survival.


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Many centers have now adopted hsTnT as a serum biomarker. This study found a serum hsTNT concentration of 33.55 ng/l 6 weeks after transplantation was found to be the best cutoff to predict death at 1 year (HR 0.16, 95%CI:0.05–0.46, P = 0.001) with a sensitivity of 90.91% and a specificity of 70.97%. In addition, survival at 5 years (HR 0.15, 95% CI 0.06–0.35, P < 0.0001) was significantly better among patients below that cutoff value. In addition, transplant vasculopathy was significantly more frequent in patients with elevated hsTNT.

Cardiac Transplantation

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