Higher Risk of Kidney Graft Failure in the Presence of Anti-Angiotensin II Type-1 Receptor Antibodies
While HLA antibodies are a well-recognized risk factor for graft loss, the role of non-HLA antibodies is less clear. Antibodies to angiotensin II type I receptor has been previously reported in patients with failing grafts. In this study, patients who developed anti-AT I receptor antibodies had a higher risk of graft failure over and above the risk associated with the development of donor-specific antibodies. Although this study could not prove causality, it does strengthen the case that these non-HLA antibodies may play a role.