Homozygosity for the toll-like receptor 2 R753Q single-nucleotide polymorphism is a risk factor for cytomegalovirus disease after liver transplantation
Innate immune responses have not been well studied in the context of CMV replication. TLR2, a cell surface pattern recognition receptor, recognizes the CMV envelope glycoprotein. This study examined a large cohort of liver transplant patients that were typed for a known single nucleotide polymorphism in the TLR2 receptor. 11% of patients had 1 or 2 alleles with the SNP. Those homozygous for the SNP had a greater risk of tissue invasive CMV disease and a higher level of viremia. This was independent of CMV serostatus, HCV infection, and allograft rejection. Further work on innate immune responses to CMV may identify a highly susceptible population that could be targeted for preventive strategies.