June 21, 2013

Hypocomplementemia in Kidney Transplant Recipients: Impact on the Risk of Infectious Complications


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Post-transplant, there is no ideal measure of predicting how immunosuppressed an individual recipient is. Fernandez-Ruiz et al. assessed complement (C3 and C4) levels at 0,1,6 months post-kidney transplant in 270 patients. Those with C3 hypocomplementemia at month 1 had greater incidences of overall infection, bacterial infection and fungal infection up to month 6 post-transplant. This study suggests that complement could be measured to determine the risk of infection post-kidney transplant. Complement deficiencies are well known to be related to infections, especially to encapsulated bacteria including invasive meningococcal disease, but also other bacterial infections. Low complement states post-transplant may reflect general over-immunosuppression. However, further research into how these patients should be monitored for infectious diseases is needed.

Renal Transplantation, Transplant Infectious Disease

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