November 1, 2010

Inflammation in Areas of Tubular Atrophy in Kidney Allograft Biopsies: A Potent Predictor of Allograft Failure


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The current criteria used to evaluate renal biopsies bases the diagnosis of acute cellular rejection on inflammation and tubulitis only in the areas of non-atrophic tissue. However, changes in atrophic areas have been ignored. In this observational study, inflammation in atrophic tissue was a strong predictor of graft failure. This was true even after adjusting for acute rejection in the non-atrophic tissue as well as changes of fibrosis and atrophy.
Renal Transplantation