June 21, 2013

Lung transplantation for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation: a single-center experience


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

This case series describes 7 patients with severe chronic graft-versus-host disease (cGvHD) associated with bronchiolitis obliterans (BO) after allogeneic hematopoietic stem cell transplantation (HCT) who underwent lung transplantation. About 20% of patients with severe cGVHD develop BO, which portends a poor prognosis. Lung transplantation may be performed for severe refractory BO. In this group, 6 patients underwent bilateral lung transplantation and 1 underwent single lung transplantation. Explanted lung pathology confirmed BO in all patients. The median survival after lung transplantation in this group was 24 months. The authors conclude that lung transplantation is a possible therapeutic option for certain patients with severe therapy-refractory BO.

Lung Transplantation

Tags: , ,