August 17, 2012

Lymphocytic bronchiolitis after lung transplantation is associated with daily changes in air pollution


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High rates of rejection in pulmonary allografts compared to other solid organ transplants may be related to constant exposure to the outside world. This study examined the impact of daily variations in air pollution on the outcome of lung transplant by correlating histologic evidence of acute rejection with daily particulate matter values at the home address up to 1 week preceding the biopsies. It was a retrospective design, examining all lung biopsies at the centre from 2001 to May 2011. Temporal changes in particulate air pollution were associated with higher rates of lymphocytic bronchiolitis, and were associated with BAL neutrophilia and lymphocytosis.

Lung Transplantation

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