December 19, 2011

Meta-Analysis of Calcineurin-Inhibitor-Sparing Regimens in Kidney Transplantation


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This is a meta-analysis of papers using a variety of approaches to reduce the toxicity of calcineurin inhibitors (CnI) in renal transplantation. Papers include a variety of approaches, such as CnI minimization, delayed introduction and avoidance. All strategies showed improvements in graft function. However, while CnI minimization or use of newer agents such as belatacept was associated with miporved graft survival, use of mTOR inhibitors such as belatacept were associated with worse graft survival.

Renal Transplantation

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