September 13, 2009

Minimization of Maintenance Immunosuppression Early After Renal Transplantation: An Interim Analysis.


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This trial is comparing patients who initially receive cyclosporine, mycophenolic acid and steroids, and are then randomized to one of three groups at six months post-transplant: Cyclosporine withdrawal, mycophenolic acid withdrawal, or conversion to everolimus with withdrawal of both cyclosporine and mycophenolic acid. The cyclosporine withdrawal arm was halted due to an unacceptably high rate of acute rejection. The primary endpoint of the study, which is biopsy changes 24 months post-transplant, has not yet been reached.

Renal Transplantation