August 14, 2011

Modifiers of complement activation for prevention of antibody-mediated injury to allografts


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Antibody mediated rejection (ABMR) involves complement activation through the classical pathway due to donor specific antibody binding to allograft endothelium. The major strength of this review is its extensive overview of complement biology and its role in the damage it incurs to the allograft during episodes of ABMR. It also covers current approaches used to neutralize classical complement activation including C5 depletion as well a novel C1 inhibitor.

Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation

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