October 30, 2012

Non-tuberculous mycobacterial infection among lung transplant recipients: a 15-year cohort study


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Incidence rates for non-tuberculous mycobacteria (NTM) colonization and disease were calculated from retrospective review of 237 consecutive lung transplants. Fifty-three patients (22.4%) isolated NTM post-transplant, and only 2 met the ATS criteria for pulmonary disease. Mycobacterium avium complex was the most common isolate (69.8%), followed by M. abscessus (9.4%) and M. gordonae (7.5%). Four patients developed surgical-site infections, 3 requiring chronic suppressive therapy and 1 died from progressive disseminated disease. Eighty-nine percent of patients who met microbiologic but not radiographic criteria for pulmonary infection were not treated and were only transiently colonized, having no impact on median survival post-transplant when compared to patients not colonized.

Lung Transplantation, Transplant Infectious Disease

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