August 14, 2011

Normothermic Ex Vivo Lung Perfusion in Clinical Lung Transplantation


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Low usage of lungs from multi-organ donors has prompted researchers to pursue innovative strategies for allowing transplantation of non-optimal lungs.  One such innovation is ex vivo lung perfusion with the use of acellular normothermic perfusate after retrieval, allowing assessment of lung viability prior to implantation.  This prospective, nonrandomized clinical trial examined primary graft dysfunction in recipients who received high-risk donor lungs deemed acceptable after four hours of ex vivo lung perfusion.  Recipients with lungs accepted by the usual criteria for transplantation during the study period were used as controls.  Twenty of  twenty-three high-risk lungs subjected to ex vivo lung perfusion were transplanted during the study period.  No significant difference in primary graft dysfunction at 72 hours was seen between the ex vivo perfused lungs and the control group, suggesting that ex vivo lung perfusion has the potential to increase transplantation of high risk lungs that would otherwise be declined.

Lung Transplantation

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